PanCan - combined cohort Back

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iCoMut Beta for


Highly significantly mutated genes
TP53
1720 patients (36%)
PIK3CA
665 patients (14%)
PTEN
372 patients (7%)
KRAS
342 patients (7%)
APC
300 patients (6%)
MLL3
294 patients (6%)
FAT1
287 patients (6%)
MLL2
270 patients (5%)
ARID1A
243 patients (5%)
VHL
235 patients (4%)
PBRM1
210 patients (4%)
NF1
206 patients (4%)
EGFR
202 patients (4%)
ATM
194 patients (4%)
PIK3R1
181 patients (3%)
BRAF
175 patients (3%)
CDKN2A
170 patients (3%)
SETD2
166 patients (3%)
CREBBP
158 patients (3%)
FBXW7
151 patients (3%)
MTOR
149 patients (3%)
RB1
141 patients (2%)
SMARCA4
137 patients (2%)
CHD4
132 patients (2%)
CTNNB1
131 patients (2%)
NRAS
126 patients (2%)
EP300
124 patients (2%)
FLT3
123 patients (2%)
GATA3
119 patients (2%)
ARID2
119 patients (2%)
MAP3K1
118 patients (2%)
KEAP1
116 patients (2%)
CDH1
115 patients (2%)
DNMT3A
112 patients (2%)
ARHGAP35
112 patients (2%)
BCOR
111 patients (2%)
SF3B1
102 patients (2%)
KDM5C
101 patients (2%)
CTCF
99 patients (2%)
NFE2L2
95 patients (2%)
KDM6A
91 patients (1%)
ERBB3
90 patients (1%)
CASP8
85 patients (1%)
ERBB2
84 patients (1%)
ASXL1
83 patients (1%)
BAP1
82 patients (1%)
FGFR2
81 patients (1%)
SMAD4
79 patients (1%)
RASA1
77 patients (1%)
RUNX1
70 patients (1%)
MAP2K4
67 patients (1%)
STK11
52 patients (1%)
SPOP
52 patients (1%)
NPM1
43 patients (0%)
AKT1
40 patients (0%)
IDH2
39 patients (0%)
CDKN1B
37 patients (0%)
HLA-A
36 patients (0%)
B2M
36 patients (0%)
U2AF1
34 patients (0%)
RPL5
32 patients (0%)
HRAS
31 patients (0%)
MYD88
31 patients (0%)
CBFB
27 patients (0%)
GPS2
25 patients (0%)
Significantly mutated genes
NOTCH1
133 patients (2%)
NSD1
127 patients (2%)
BCLAF1
117 patients (2%)
MLL4
114 patients (2%)
POLE
113 patients (2%)
MGA
111 patients (2%)
STAG2
106 patients (2%)
CHD8
100 patients (2%)
TP53BP1
85 patients (1%)
ASXL2
75 patients (1%)
CNBD1
73 patients (1%)
PLCG2
73 patients (1%)
SETDB1
70 patients (1%)
IDH1
67 patients (1%)
SMC3
65 patients (1%)
GNPTAB
59 patients (1%)
DDX3X
58 patients (1%)
TBL1XR1
57 patients (1%)
ACVR1B
53 patients (1%)
RBM10
53 patients (1%)
DNAH12
51 patients (1%)
HSP90AB1
51 patients (1%)
FGFR3
50 patients (1%)
MBD1
50 patients (1%)
IRF6
46 patients (0%)
ZNF483
45 patients (0%)
SERPINB13
42 patients (0%)
CNKSR1
42 patients (0%)
ZNF180
42 patients (0%)
SMARCB1
36 patients (0%)
MAP2K1
36 patients (0%)
EZH1
34 patients (0%)
SEPT12
31 patients (0%)
BRE
29 patients (0%)
OMA1
28 patients (0%)
CEP76
28 patients (0%)
FAM166A
27 patients (0%)
INTS12
26 patients (0%)
BHMT2
26 patients (0%)
RHOA
26 patients (0%)
ODAM
24 patients (0%)
HIST1H4E
22 patients (0%)
RAC1
21 patients (0%)
PDCD2L
21 patients (0%)
ATP5B
18 patients (0%)
FGFBP1
17 patients (0%)
TIMM17A
15 patients (0%)
APOL2
14 patients (0%)
RPS2
10 patients (0%)
Genes near significance
SPEN
151 patients (3%)
MLL
126 patients (2%)
NCOR1
122 patients (2%)
COL4A6
109 patients (2%)
DSG4
86 patients (1%)
CDK12
77 patients (1%)
PPP2R1A
67 patients (1%)
UBN2
62 patients (1%)
POLR2B
62 patients (1%)
CPT1A
59 patients (1%)
USP7
57 patients (1%)
EPS8
52 patients (1%)
GPR156
51 patients (1%)
SOX6
50 patients (1%)
MTM1
48 patients (1%)
MTF1
45 patients (0%)
ELF1
43 patients (0%)
TBC1D12
40 patients (0%)
SLC38A8
39 patients (0%)
EIF4A2
39 patients (0%)
TRAF3
37 patients (0%)
ZNF782
35 patients (0%)
SAMSN1
32 patients (0%)
HIST1H3B
32 patients (0%)
STIP1
30 patients (0%)
PSTPIP2
26 patients (0%)
KLHL8
25 patients (0%)
ATP6V1C1
25 patients (0%)
RBM11
24 patients (0%)
EIF2S2
20 patients (0%)
C2orf70
15 patients (0%)
SPATA12
6 patients (0%)
Click on a gene to see details.

Notes


• Gene name color indicates: known cancer genes | highly compelling novel candidate cancer genes | other candidates

Data details


Mutation list for PanCan
Q-Q plots for PanCan