NRAS Back

neuroblastoma RAS viral (v-ras) oncogene homolog

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NCBI Description of NRAS

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NRAS is highly significantly mutated in
Melanoma
MEL
28 patients (23%)
Multiple myeloma
MM
37 patients (17%)
Colorectal
CRC
22 patients (9%)
Acute myeloid leukemia
AML
15 patients (7%)
combined cohort
PanCan
126 patients (2%)
NRAS is significantly mutated in
Endometrial
UCEC
9 patients (3%)
NRAS is near significance in
Chronic lymphocytic leukemia
CLL
2 patients (1%)
Lung adenocarcinoma
LUAD
4 patients (0%)
Ovarian
OV
2 patients (0%)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for NRAS