ATP5B Back

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ATP5B
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.

Community Annotation of ATP5B Add / Edit ATP5B: Annotations

No community annotations yet for ATP5B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ATP5B is highly significantly mutated in
ATP5B is significantly mutated in
combined cohort
PanCan
18 patients (0%)
ATP5B is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ATP5B