mechanistic target of rapamycin (serine/threonine kinase)

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NCBI Description of MTOR

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Community Annotation of MTOR Add / Edit MTOR: Annotations

No community annotations yet for MTOR.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MTOR is highly significantly mutated in
Kidney clear cell
25 patients (5%)
combined cohort
149 patients (3%)
MTOR is significantly mutated in
MTOR is near significance in
27 patients (10%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MTOR