FAT1 Back

FAT tumor suppressor homolog 1 (Drosophila)

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NCBI Description of FAT1

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.

Community Annotation of FAT1 Add / Edit FAT1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


FAT1 is highly significantly mutated in
Head and neck
77 patients (20%)
combined cohort
287 patients (6%)
FAT1 is significantly mutated in
42 patients (16%)
FAT1 is near significance in
Lung adenocarcinoma
56 patients (13%)
Lung squamous cell carcinoma
21 patients (11%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for FAT1