RAC1 Back

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

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NCBI Description of RAC1

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of RAC1 Add / Edit RAC1: Annotations

No community annotations yet for RAC1.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RAC1 is highly significantly mutated in
5 patients (4%)
Head and neck
10 patients (2%)
RAC1 is significantly mutated in
combined cohort
21 patients (0%)
RAC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RAC1