KRAS Back

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

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NCBI Description of KRAS

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KRAS is highly significantly mutated in
Colorectal
CRC
102 patients (43%)
Lung adenocarcinoma
LUAD
108 patients (26%)
Endometrial
UCEC
54 patients (21%)
Multiple myeloma
MM
45 patients (21%)
combined cohort
PanCan
342 patients (7%)
Acute myeloid leukemia
AML
8 patients (4%)
Breast
BRCA
6 patients (0%)
KRAS is significantly mutated in
KRAS is near significance in
Diffuse large B-cell lymphoma
DLBCL
3 patients (5%)
Esophageal adenocarcinoma
ESO
5 patients (3%)
Ovarian
OV
2 patients (0%)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for KRAS