EP300 Back

E1A binding protein p300

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NCBI Description of EP300

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Community Annotation of EP300 Add / Edit EP300: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EP300 is highly significantly mutated in
combined cohort
124 patients (2%)
EP300 is significantly mutated in
22 patients (8%)
Head and neck
27 patients (7%)
EP300 is near significance in
Lung squamous cell carcinoma
8 patients (4%)
7 patients (0%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EP300