TP53 Back

tumor protein p53

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NCBI Description of TP53

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons.

Community Annotation of TP53 Add / Edit TP53: Annotations

Added by Daniel Menendez

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Added by Nour Al deen

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Sort mutations by: Tumor type  Mutation type  Position  
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TP53 is highly significantly mutated in
Ovarian
OV
300 patients (94%)
Lung squamous cell carcinoma
LUSC
149 patients (83%)
Head and neck
HNSC
258 patients (67%)
Esophageal adenocarcinoma
ESO
92 patients (65%)
Colorectal
CRC
122 patients (52%)
Bladder
BLCA
51 patients (51%)
Lung adenocarcinoma
LUAD
207 patients (51%)
combined cohort
PanCan
1720 patients (36%)
Breast
BRCA
281 patients (31%)
Glioblastoma multiforme
GBM
84 patients (28%)
Endometrial
UCEC
70 patients (28%)
Diffuse large B-cell lymphoma
DLBCL
13 patients (22%)
Melanoma
MEL
21 patients (17%)
Chronic lymphocytic leukemia
CLL
17 patients (10%)
Acute myeloid leukemia
AML
16 patients (8%)
Multiple myeloma
MM
15 patients (7%)
Kidney clear cell
KIRC
13 patients (3%)
TP53 is significantly mutated in
Prostate
PRAD
5 patients (3%)
TP53 is near significance in
Carcinoid
CARC
3 patients (5%)
Medulloblastoma
MED
3 patients (3%)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TP53