histone cluster 1, H3b

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NCBI Description of HIST1H3B

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HIST1H3B is highly significantly mutated in
HIST1H3B is significantly mutated in
10 patients (1%)
HIST1H3B is near significance in
Diffuse large B-cell lymphoma
4 patients (6%)
combined cohort
32 patients (0%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HIST1H3B