APC Back

adenomatous polyposis coli

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NCBI Description of APC

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

APC is highly significantly mutated in
Colorectal
CRC
179 patients (76%)
combined cohort
PanCan
300 patients (6%)
APC is significantly mutated in
APC is near significance in
Lung adenocarcinoma
LUAD
28 patients (6%)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for APC