APC Back

adenomatous polyposis coli

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of APC

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Community Annotation of APC Add / Edit APC: Annotations

No community annotations yet for APC.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


APC is highly significantly mutated in
179 patients (76%)
combined cohort
300 patients (6%)
APC is significantly mutated in
APC is near significance in
Lung adenocarcinoma
28 patients (6%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for APC