Explore dataset by tumor types Show Annotation Activity

Click on a tumor type to see what genes are significantly mutated in it (and other details).
Acute myeloid leukemia
AML
196 patients
Bladder
BLCA
99 patients
Breast
BRCA
892 patients
Carcinoid
CARC
54 patients
Chronic lymphocytic leukemia
CLL
159 patients
Colorectal
CRC
233 patients
Diffuse large B-cell lymphoma
DLBCL
58 patients
Esophageal adenocarcinoma
ESO
141 patients
Glioblastoma multiforme
GBM
291 patients
Head and neck
HNSC
384 patients
Kidney clear cell
KIRC
417 patients
Lung adenocarcinoma
LUAD
405 patients
Lung squamous cell carcinoma
LUSC
178 patients
Medulloblastoma
MED
92 patients
Melanoma
MEL
118 patients
Multiple myeloma
MM
207 patients
Neuroblastoma
NB
81 patients
Ovarian
OV
316 patients
combined cohort
PanCan
4742 patients
Prostate
PRAD
138 patients
Rhabdoid tumor
RHAB
35 patients
Endometrial
UCEC
248 patients

Explore dataset by Genes

Click on a gene name to see what tumor types it is significantly mutated in (and other details).
TP53
36% of all patients
PIK3CA
14% of all patients
PTEN
7% of all patients
KRAS
7% of all patients
APC
6% of all patients
MLL3
6% of all patients
FAT1
6% of all patients
MLL2
5% of all patients
ARID1A
5% of all patients
VHL
4% of all patients
PBRM1
4% of all patients
NF1
4% of all patients
EGFR
4% of all patients
ATM
4% of all patients
PIK3R1
3% of all patients
BRAF
3% of all patients
CDKN2A
3% of all patients
SETD2
3% of all patients
CREBBP
3% of all patients
FBXW7
3% of all patients
SPEN
3% of all patients
MTOR
3% of all patients
RB1
2% of all patients
SMARCA4
2% of all patients
NOTCH1
2% of all patients

Explore by Figures

Or browse clickable interactive versions of figures from the paper.
Figure 2: Genes in each tumor type
Fig2.thumbnail
Figure 3: Tumor-type-specific and pan-cancer genes
Fig3.thumbnail
Figure 5: Discovery power in each tumor type
Fig5.thumbnail
Power Calculator
Powercalc
Figure S1: Background mutation frequencies across cancer
Figs1.thumbnail

Cite TumorPortal

Using this data? Please cite  Lawrence et al. Nature (2014)

Annotation Activity & Updates

Variants

Variant ID Owner Date
XPO1 p.E571A Yiwei Li 2020-05-11 14:50 pm
KRAS p.G13D chris mademlis 2016-12-08 07:17 am
BRAF p.V600E Cláudio Santos 2015-10-07 07:35 am
SUFU p.S342N 2015-07-27 02:14 am
TCFL5 p.K341N Nuria Gironés 2015-06-19 11:49 am
BRAF p.V600E Amaro Taylor-Weiner 2015-01-07 15:45 pm
RIT1 p.F82L Alice Berger 2015-01-07 15:35 pm
RIT1 p.M90I Alice Berger 2015-01-07 15:33 pm
PIK3R1 p.V662_splice Eli Van Allen 2015-01-06 16:34 pm

Genes

Symbol Owner Date

Recent Votes

Variant/Gene Owner Vote Date
OSMR Deepak Parashar
2019-07-19 14:56 pm
PIK3R1 Eli Van Allen
2015-01-06 16:35 pm
ERCC2 Eli Van Allen
2015-02-02 11:37 am
BRAF p.V600E Amaro Taylor-Weiner
2015-01-07 15:45 pm
ERCC2 Eli Van Allen
2015-02-02 11:37 am
PIK3R1 Eli Van Allen
2015-01-06 16:35 pm
PIK3R1 Eli Van Allen
2015-01-06 16:35 pm
RIT1 p.F82L Alice Berger
2015-01-07 15:35 pm
C6orf165 Andre Bernards
2015-01-07 15:56 pm
PIK3R1 p.V662_splice Eli Van Allen
2015-01-06 16:34 pm
RIT1 Alice Berger
2015-01-07 15:39 pm
RIT1 p.F82L Alice Berger
2015-01-07 15:35 pm
C6orf165 Andre Bernards
2015-01-07 15:56 pm
BRAF p.V600E Amaro Taylor-Weiner
2015-01-07 15:45 pm
RIT1 p.F82L Alice Berger
2015-01-07 15:35 pm
C6orf165 Andre Bernards
2015-01-07 15:56 pm
BRAF p.V600E Amaro Taylor-Weiner
2015-01-07 15:45 pm
PIK3R1 p.V662_splice Eli Van Allen
2015-01-06 16:34 pm
PIK3R1 Eli Van Allen
2015-01-06 16:35 pm
PIK3R1 p.V662_splice Eli Van Allen
2015-01-06 16:34 pm

Most Active Variants

Variant ID Annotations
BRAF p.V600E 2
SUFU p.S342N 1
RIT1 p.F82L 1
XPO1 p.E571A 1
RIT1 p.M90I 1
KRAS p.G13D 1
PIK3R1 p.V662_splice 1
TCFL5 p.K341N 1

Most Active Genes

Symbol Annotations

Highest Rated Users

User Aggregate Upvotes
Eli Van Allen 9
Alice Berger 4
Andre Bernards 3
Amaro Taylor-Weiner 3
Deepak Parashar 1
Lee Lawton 0
Eila Arich-Landkof 0
Michael Reich 0
Cancer Development 0
Jon Bistline 0
Jacopo De Santa 0
A Ghazani 0
Lea Starita 0
Jill Mesirov 0
Ted Liefeld 0
Joanne Kotz 0
Gad Getz 0
Michael Lawrence 0
Jonathan Bistline 0
Atanas Kamburov 0
Eejung Kim 0
Paul Savage 0
Eva Samal 0
June-Koo Lee 0
0
Srivatsan Raghavan 0
Ankita Singh 0
Julian Hess 0
Xin Lu 0
SEKHAR DURAISAMY 0
Rui Fang 0
Solip Park 0
Johan Lindberg 0
Samuel Freeman 0
Jianing Xu 0
Michael Sharpnack 0
Aayush Raman 0
Rodrigo Toledo 0
Jon Goldstein 0
Lihua Zou 0
Benjamin Drapkin 0
Xin Jin 0
Uri Ben-David 0
Susan Bullman 0
Bradley Murray 0
Juliann Shih 0
Matthew Oser 0
Andrew Cherniack 0
Joaquim Bellmunt 0
Alexandru Floares 0

Most Active Users

User Annotations
Eli Van Allen 3
Alice Berger 3
Viswanathan Palanisamy 3
Tanasan Sirirat 2
Andrew Cherniack 2
2
Venkat Addala 1
Nilofer 1
Heesun Cheong 1
Shoshana Levy 1
Yiwei Li 1
shiv verma 1
Deepak Parashar 1
Kyosuke Mukae 1
Meiou Dai 1
Dinesh M G 1
LI-JIE LI 1
Amaro Taylor-Weiner 1
Andre Bernards 1
MARIA GIULIA MANZIONE 1
Shengfang Jin 1
Utsa Bhaduri 1
Marta Rodriguez Martinez 1
Hanna Sowar 1
Jeffery Chakedis 1
chris mademlis 1
Peiyong Guan 1
Nour Al deen 1
Guido Marcucci 1
Daniel Menendez 1
Agostino Lacroix 1
Rachel Frieman 1
Cláudio Santos 1
Michael Boettcher 1
Deepak Jha 1
1
ben benbenben 1
Nuria Gironés 1
Cyrus Hedvat 1
Vera Kaiser 1
Peter King 1
Lee Lawton 0
Uri Ben-David 0
Susan Bullman 0
Bradley Murray 0
Juliann Shih 0
Matthew Oser 0
Benjamin Drapkin 0
Joaquim Bellmunt 0
Alexandru Floares 0