MAP4K3 Back

mitogen-activated protein kinase kinase kinase kinase 3

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NCBI Description of MAP4K3

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Community Annotation of MAP4K3 Add / Edit MAP4K3: Annotations

No community annotations yet for MAP4K3.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MAP4K3 is highly significantly mutated in
MAP4K3 is significantly mutated in
Head and neck
7 patients (1%)
MAP4K3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MAP4K3