inositol polyphosphate phosphatase-like 1

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NCBI Description of INPPL1

The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


INPPL1 is highly significantly mutated in
INPPL1 is significantly mutated in
19 patients (7%)
INPPL1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for INPPL1