ZP2 Back

zona pellucida glycoprotein 2 (sperm receptor)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ZP2

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.

Community Annotation of ZP2 Add / Edit ZP2: Annotations

No community annotations yet for ZP2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ZP2 is highly significantly mutated in
(none)
ZP2 is significantly mutated in
(none)
ZP2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ZP2