ZMPSTE24 Back

zinc metallopeptidase (STE24 homolog, S. cerevisiae)

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NCBI Description of ZMPSTE24
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.

Community Annotation of ZMPSTE24 Add / Edit ZMPSTE24: Annotations

No community annotations yet for ZMPSTE24.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ZMPSTE24 is highly significantly mutated in
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ZMPSTE24 is significantly mutated in
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ZMPSTE24 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ZMPSTE24