ZMIZ1 Back

zinc finger, MIZ-type containing 1

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NCBI Description of ZMIZ1
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia.

Community Annotation of ZMIZ1 Add / Edit ZMIZ1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ZMIZ1 is highly significantly mutated in
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ZMIZ1 is significantly mutated in
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ZMIZ1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ZMIZ1