ZIC3 Back

Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)

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NCBI Description of ZIC3
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of ZIC3 Add / Edit ZIC3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ZIC3 is highly significantly mutated in
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ZIC3 is significantly mutated in
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ZIC3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ZIC3