ZIC1 Back

Zic family member 1 (odd-paired homolog, Drosophila)

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NCBI Description of ZIC1

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ZIC1 is highly significantly mutated in
ZIC1 is significantly mutated in
ZIC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ZIC1