zinc finger, FYVE domain containing 9

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NCBI Description of ZFYVE9

This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ZFYVE9 is highly significantly mutated in
ZFYVE9 is significantly mutated in
ZFYVE9 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ZFYVE9