ZFYVE1 Back

zinc finger, FYVE domain containing 1

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NCBI Description of ZFYVE1
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution. Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ZFYVE1 is highly significantly mutated in
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ZFYVE1 is significantly mutated in
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ZFYVE1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ZFYVE1