ZFPM2 Back

zinc finger protein, multitype 2

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NCBI Description of ZFPM2
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ZFPM2 is highly significantly mutated in
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ZFPM2 is significantly mutated in
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ZFPM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ZFPM2