ZFP36L1 Back

zinc finger protein 36, C3H type-like 1

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NCBI Description of ZFP36L1
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ZFP36L1 is highly significantly mutated in
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ZFP36L1 is significantly mutated in
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ZFP36L1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ZFP36L1