zinc finger and AT hook domain containing

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NCBI Description of ZFAT

This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Community Annotation of ZFAT Add / Edit ZFAT: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ZFAT is highly significantly mutated in
ZFAT is significantly mutated in
ZFAT is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ZFAT