ZEB2 Back

zinc finger E-box binding homeobox 2

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NCBI Description of ZEB2
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of ZEB2 Add / Edit ZEB2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ZEB2 is highly significantly mutated in
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ZEB2 is significantly mutated in
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ZEB2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ZEB2