ZEB1 Back

zinc finger E-box binding homeobox 1

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NCBI Description of ZEB1

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.

Community Annotation of ZEB1 Add / Edit ZEB1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ZEB1 is highly significantly mutated in
ZEB1 is significantly mutated in
ZEB1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ZEB1