YWHAZ Back

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

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NCBI Description of YWHAZ
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

YWHAZ is highly significantly mutated in
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YWHAZ is significantly mutated in
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YWHAZ is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for YWHAZ