YWHAH Back

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

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NCBI Description of YWHAH
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder.

Community Annotation of YWHAH Add / Edit YWHAH: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

YWHAH is highly significantly mutated in
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YWHAH is significantly mutated in
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YWHAH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for YWHAH