YWHAG Back

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

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NCBI Description of YWHAG
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

YWHAG is highly significantly mutated in
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YWHAG is significantly mutated in
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YWHAG is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for YWHAG