XRN2 Back

5'-3' exoribonuclease 2

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NCBI Description of XRN2
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known.

Community Annotation of XRN2 Add / Edit XRN2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

XRN2 is highly significantly mutated in
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XRN2 is significantly mutated in
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XRN2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for XRN2