XRN1 Back

5'-3' exoribonuclease 1

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NCBI Description of XRN1

SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM, Apr 2004].

Community Annotation of XRN1 Add / Edit XRN1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


XRN1 is highly significantly mutated in
XRN1 is significantly mutated in
XRN1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for XRN1