XRCC3 Back

X-ray repair complementing defective repair in Chinese hamster cells 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of XRCC3

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.

Community Annotation of XRCC3 Add / Edit XRCC3: Annotations

No community annotations yet for XRCC3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


XRCC3 is highly significantly mutated in
XRCC3 is significantly mutated in
XRCC3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for XRCC3