XRCC3 Back

X-ray repair complementing defective repair in Chinese hamster cells 3

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NCBI Description of XRCC3
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

XRCC3 is highly significantly mutated in
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XRCC3 is significantly mutated in
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XRCC3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for XRCC3