XRCC2 Back

X-ray repair complementing defective repair in Chinese hamster cells 2

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NCBI Description of XRCC2

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


XRCC2 is highly significantly mutated in
XRCC2 is significantly mutated in
XRCC2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for XRCC2