XRCC1 Back

X-ray repair complementing defective repair in Chinese hamster cells 1

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NCBI Description of XRCC1
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Community Annotation of XRCC1 Add / Edit XRCC1: Annotations

No community annotations yet for XRCC1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

XRCC1 is highly significantly mutated in
(none)
XRCC1 is significantly mutated in
(none)
XRCC1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for XRCC1