X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

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NCBI Description of XPNPEP1

This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


XPNPEP1 is highly significantly mutated in
XPNPEP1 is significantly mutated in
XPNPEP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for XPNPEP1