XPA Back

xeroderma pigmentosum, complementation group A

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NCBI Description of XPA
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of XPA Add / Edit XPA: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

XPA is highly significantly mutated in
(none)
XPA is significantly mutated in
(none)
XPA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for XPA