WRAP53 Back

WD repeat containing, antisense to TP53

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of WRAP53
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene.

Community Annotation of WRAP53 Add / Edit WRAP53: Annotations

No community annotations yet for WRAP53.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

WRAP53 is highly significantly mutated in
(none)
WRAP53 is significantly mutated in
(none)
WRAP53 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for WRAP53