WNK2 Back

WNK lysine deficient protein kinase 2

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NCBI Description of WNK2

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.

Community Annotation of WNK2 Add / Edit WNK2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


WNK2 is highly significantly mutated in
WNK2 is significantly mutated in
WNK2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for WNK2