WIPF1 Back

WAS/WASL interacting protein family, member 1

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NCBI Description of WIPF1
This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

WIPF1 is highly significantly mutated in
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WIPF1 is significantly mutated in
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WIPF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for WIPF1