WIF1 Back

WNT inhibitory factor 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of WIF1
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers.

Community Annotation of WIF1 Add / Edit WIF1: Annotations

No community annotations yet for WIF1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

WIF1 is highly significantly mutated in
(none)
WIF1 is significantly mutated in
(none)
WIF1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for WIF1