WFDC2 Back

WAP four-disulfide core domain 2

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NCBI Description of WFDC2
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

WFDC2 is highly significantly mutated in
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WFDC2 is significantly mutated in
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WFDC2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for WFDC2