WDFY3 Back

WD repeat and FYVE domain containing 3

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NCBI Description of WDFY3

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


WDFY3 is highly significantly mutated in
WDFY3 is significantly mutated in
WDFY3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for WDFY3