NCBI Description of VPS37A
|This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.|
Community Annotation of VPS37A Add / Edit VPS37A: Annotations
No community annotations yet for VPS37A.
Click on a tumor type to see its full list of significant genes.