VPS35 Back

vacuolar protein sorting 35 homolog (S. cerevisiae)

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NCBI Description of VPS35
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.

Community Annotation of VPS35 Add / Edit VPS35: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VPS35 is highly significantly mutated in
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VPS35 is significantly mutated in
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VPS35 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for VPS35