VPS25 Back

vacuolar protein sorting 25 homolog (S. cerevisiae)

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NCBI Description of VPS25
VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008].

Community Annotation of VPS25 Add / Edit VPS25: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VPS25 is highly significantly mutated in
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VPS25 is significantly mutated in
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VPS25 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for VPS25