VPS24 Back

vacuolar protein sorting 24 homolog (S. cerevisiae)

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NCBI Description of VPS24
This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene.

Community Annotation of VPS24 Add / Edit VPS24: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VPS24 is highly significantly mutated in
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VPS24 is significantly mutated in
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VPS24 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for VPS24