VPS18 Back

vacuolar protein sorting 18 homolog (S. cerevisiae)

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NCBI Description of VPS18
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.

Community Annotation of VPS18 Add / Edit VPS18: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VPS18 is highly significantly mutated in
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VPS18 is significantly mutated in
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VPS18 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for VPS18