VPS16 Back

vacuolar protein sorting 16 homolog (S. cerevisiae)

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NCBI Description of VPS16
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of VPS16 Add / Edit VPS16: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VPS16 is highly significantly mutated in
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VPS16 is significantly mutated in
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VPS16 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for VPS16