VPS11 Back

vacuolar protein sorting 11 homolog (S. cerevisiae)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of VPS11

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.

Community Annotation of VPS11 Add / Edit VPS11: Annotations

No community annotations yet for VPS11.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VPS11 is highly significantly mutated in
(none)
VPS11 is significantly mutated in
(none)
VPS11 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for VPS11