VEGFB Back

vascular endothelial growth factor B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of VEGFB
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Community Annotation of VEGFB Add / Edit VEGFB: Annotations

No community annotations yet for VEGFB.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VEGFB is highly significantly mutated in
(none)
VEGFB is significantly mutated in
(none)
VEGFB is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for VEGFB